The 18th conference of the International Study Group for Systems Biology (ISGSB) will be held in Tromsø, Norway from the 24th to the 28th of September 2018 at Sommarøy Arctic Hotel Tromsø. The aim of the conference is to foster tightly linked experimental modeling approaches to unravel complex biological processes and to provide a platform for exchange and discussion of new developments in the field. The topics range from evolutionary development over biotechnology to systems medicine.