H1 human embryonic stem cell whole-cell model

The H1 human embryonic stem cell (hESC) model is the first step toward whole-cell models of human cells. The model will represent the core cellular functions of all human cells including their metabolism, DNA replication, transcription, translation, protein complexation, RNA and protein degradation, and division. The model focuses on H1-hESCs because ESCs behave as individual [...]

May 2nd, 2018|Model|

Mycoplasma genitalium whole-cell model

The M. genitalium whole-cell model was the first model that represented each characterized gene function of an organism. The model is composed of 28 submodels of 28 cellular processes. In total, the model represents the functions of 401 genes, 722 compounds, 1,857 reactions, and 1,836 parameters. In addition to demonstrating the feasibility of whole-cell models, [...]

September 12th, 2016|Model|

Mycoplasma pneumoniae whole-cell model

The Mycoplasma pneumoniae whole-cell model will be the most comprehensive, most systematically constructed, and most extensible whole-cell model to date. The model will represent all of the major cellular functions of M. pneumoniae, including the function each characterized gene. The model will be based primarily on M. pneumoniae genomic data. The model will be used [...]

May 2nd, 2018|Model|

Random WC model generator

The random whole-cell model generator is a tool for generating WC models that represent user-specified numbers of genes, RNA, proteins, and reactions of an archetypal bacterium. The models generated by the model generator represent the metabolism, replication, transcription, translation, RNA and protein degradation, and cell division of a typical bacterium. The archetypal bacterium model generator [...]

May 2nd, 2018|Model, Software, TR&D 1 - Software|