Jonathan Karr

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So far Jonathan Karr has created 51 blog entries.

Mycoplasma genitalium whole-cell model

The M. genitalium whole-cell model was the first model that represented each characterized gene function of an organism. The model is composed of 28 submodels of 28 cellular processes. In total, the model represents the functions of 401 genes, 722 compounds, 1,857 reactions, and 1,836 parameters. In addition to demonstrating the feasibility of whole-cell models, [...]

2019-09-17T10:37:14-07:00September 12th, 2016|Model|

Mycoplasma pneumoniae whole-cell model

The Mycoplasma pneumoniae whole-cell model will be the most comprehensive, most systematically constructed, and most extensible whole-cell model to date. The model will represent all of the major cellular functions of M. pneumoniae, including the function each characterized gene. The model will be based primarily on M. pneumoniae genomic data. The model will be used [...]

2019-09-17T10:41:02-07:00May 2nd, 2018|Model|

Random WC model generator

The Random Whole-cell model generator is a tool for generating WC models that represent user-specified numbers of genes, RNA, proteins, and reactions of an archetypal bacterium. The models generated by the model generator represent the metabolism, replication, transcription, translation, RNA and protein degradation, and cell division of a typical bacterium. The archetypal bacterium model [...]

2022-07-26T19:43:39-07:00May 2nd, 2018|Model, Software, TR&D 1 - Software|

SemGen

SemGen is an experimental software tool for automating the modular composition and decomposition of biosimulation models. SemGen facilitates the construction of complex, integrated models, and the swift extraction of reusable sub-models from larger ones. SemGen relies on the semantically-rich SemSim model description format to help automate these modeling tasks. With SemGen, users can: Visualize [...]

2022-07-26T22:34:36-07:00September 12th, 2016|Software, TR&D 2 - Software|

Tellurium

Tellurium (te.) is a Python environment based on spyder2 IDE. It combines a number of existing libraries, including libSBML, libRoadRunner (including libStruct), libAntimony, and is extensible via telPlugins. In addition, other tools kits such as matplotlib and NumPy are used to provide additional analysis and plotting support. On Windows, Tellurium comes with pip, so [...]

2022-07-26T20:02:17-07:00September 12th, 2016|Software|

VCell

VCell (Virtual Cell) is a comprehensive platform for modeling cell biological systems that are built on a central database and disseminated as a web application. VCell permits the construction of models, application of numerical solvers to perform simulations, and analysis of simulation results, offering the choice of multiple physical approximations and simulation technologies to [...]

2022-07-26T20:00:44-07:00September 12th, 2016|Software, TR&D 3 - Software|

WC-KB

Whole-cell KB (WC-KB) is a data model for describing the experimental data needed to build, calibrate, and validate a whole-cell model. WC-KB includes a command line program and a Python API. Whole-cell KB

2022-07-26T20:03:20-07:00September 12th, 2016|Software, TR&D 1 - Software|

WC-KB-Gen

WC-KB-Gen is a Python framework for programmatically constructing knowledge bases for whole-cell models. WC-KB-Gen helps modelers retrieve data from external sources, organize this data, and record the provenance of this data. In turn, WC-KB-Gen helps modelers scalably, reproducibly, and comprehensibly discover and aggregate data for whole-cell models. Learn more

2022-07-26T20:10:39-07:00May 2nd, 2018|Software, TR&D 1 - Software|

WC-Model-Gen

WC-Model-Gen is a Python framework for programmatically constructing whole-cell models from large datasets described with WC-KB. WC-Model-Gen helps modelers retrieve data from a WC-KB and use the data to scalably design species and reactions. In turn, WC-Model-Gen helps modelers build models scalably, reproducibly, and comprehensibly. WC-Model-Gen on GitHub

2022-07-26T20:16:20-07:00May 2nd, 2018|Software, TR&D 1 - Software|
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