The M. genitalium whole-cell model was the first model that represented each characterized gene function of an organism. The model is composed of 28 submodels of 28 cellular processes. In total, the model represents the functions of 401 genes, 722 compounds, 1,857 reactions, and 1,836 parameters. In addition to demonstrating the feasibility of whole-cell models, the model has been used to gain new insights into cell cycle regulation, learn unknown parameters, and suggest new uses of existing antibiotics for Mycoplasmas.
Mycoplasma genitalium whole-cell model