The Simulation Experiment Description Markup Language (SED-ML) is a standardized, community-based format that explicitly describes simulation processes for biochemical models, ensuring that researchers who are interested in a published model can efficiently reproduce and build upon that model. Its use is independent of specific operating systems or versions of software. The CRBM and COMBINE community actively collaborate to enhance the existing SED-ML libraries and specifications. Lucian Smith and other members of the COMBINE community have worked to develop the most recent version of SED-ML, Level 1 Version 4, which features Kinetic Simulation Algorithm Ontology (KiSAO) integration. KiSAO terms expedite setting up new experiments–users can simply add a new KiSAO term to the SED-ML file. Currently, the CRBM is also developing a common API that can export simulation commands directly to SED-ML.
